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研究業績

これまでの​主な研究業績です。

論文

1.    Basak M, Chaudhary DK, Takahashi RU, Yamamoto Y, Tiwari S, Tahara H, Mittal A. Immunocyte Derived Exosomes: Insight into the Potential Chemo-immunotherapeutic Nanocarrier Targeting the Tumor Microenvironment. ACS Biomaterials Science and Engineering. 2023;9(1):20-39.10.1021/acsbiomaterials.2c00893

2.    Lin CY, Nhat Nguyen UT, Hsieh HY, Tahara H, Chang YS, Wang BY, Gu BC, Dai YH, Wu CC, Tsai IJ, Fan YJ. Peptide-based electrochemical sensor with nanogold enhancement for detecting rheumatoid arthritis. Talanta. 2022;236.10.1016/j.talanta.2021.122886

3.    Ko K, Takahashi K, Nagashima S, Bunthen E, Ouoba S, Hussain MRA, Akita T, Sugiyama A, Sakaguchi T, Tahara H, Ohge H, Ohdan H, Kubo T, Ishikawa N, Takafuta T, Fujii Y, Mimori M, Okada F, Kishita E, Ariyoshi K, Kuwabara M, Tanaka J. Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan. Scientific Reports. 2022;12(1).10.1038/s41598-022-04952-2

4.    Kato M, Ogata H, Tahara H, Shimamoto A, Takekita Y, Koshikawa Y, Nishida K, Nonen S, Higasa K, Kinoshita T. Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways. International Journal of Molecular Sciences. 2022;23(7).10.3390/ijms23073873

5.    Ikeuchi Y, Ochi H, Motoda C, Tokuyama T, Okubo Y, Okamura S, Miyauchi S, Miyamoto S, Uotani Y, Onohara Y, Nakashima M, Akiyama R, Tahara H, Chayama K, Kihara Y, Nakano Y. Plasma MicroRNAs as noninvasive diagnostic biomarkers in patients with Brugada syndrome. PLoS ONE. 2022;17(5 5).10.1371/journal.pone.0261390

6.    Hsieh HY, Luo JX, Shen YH, Lo SC, Hsu YC, Tahara H, Fan YJ, Wei PK, Sheen HJ. A nanofluidic preconcentrator integrated with an aluminum-based nanoplasmonic sensor for Epstein-Barr virus detection. Sensors and Actuators B: Chemical. 2022;355.10.1016/j.snb.2021.131327

7.    Hsieh HY, Chang R, Huang YY, Juan PH, Tahara H, Lee KY, Vo DNK, Tsai MH, Wei PK, Sheen HJ, Fan YJ. Continuous polymerase chain reaction microfluidics integrated with a gold-capped nanoslit sensing chip for Epstein-Barr virus detection. Biosensors and Bioelectronics. 2022;195.10.1016/j.bios.2021.113672

8.    Han J, Hayashi S, Takahashi RU, Hirohata R, Kurokawa T, Tashiro M, Yamamoto Y, Okada M, Tahara H. Leukocyte Telomeric G-Tail Length Shortening Is Associated with Esophageal Cancer Recurrence. Journal of Clinical Medicine. 2022;11(24).10.3390/jcm11247385

9.    Fan YJ, Hsieh HY, Huang YR, Tsao C, Lee CM, Tahara H, Wu YC, Sheen HJ, Chen BC. Development of a water refractive index-matched microneedle integrated into a light sheet microscopy system for continuous embryonic cell imaging. Lab on a Chip. 2022;22(3):584-91.10.1039/d1lc00827g

10.  Yano K, Takahashi RU, Yamamoto Y, Kan S, Sakagami H, Tahara H, Shiotani B, Abe J, Shidooka T, Sudo Y. PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA. Journal of Biological Chemistry. 2021;297(1).10.1016/j.jbc.2021.100882

11.  Verweij FJ, Balaj L, Boulanger CM, Carter DRF, Compeer EB, D’Angelo G, El Andaloussi S, Goetz JG, Gross JC, Hyenne V, Krämer-Albers EM, Lai CP, Loyer X, Marki A, Momma S, Nolte-‘t Hoen ENM, Pegtel DM, Peinado H, Raposo G, Rilla K, Tahara H, Théry C, van Royen ME, Vandenbroucke RE, Wehman AM, Witwer K, Wu Z, Wubbolts R, van Niel G. The power of imaging to understand extracellular vesicle biology in vivo. Nature Methods. 2021;18(9):1013-26.10.1038/s41592-021-01206-3

12.  Lu YJ, Hsieh HY, Kuo WC, Wei PK, Sheen HJ, Tahara H, Chiu TW, Fan YJ. Nanoplasmonic structure of a polycarbonate substrate integrated with parallel microchannels for label-free multiplex detection. Polymers. 2021;13(19).10.3390/polym13193294

13.  Ko K, Nagashima S, Bunthen E, Ouoba S, Akita T, Sugiyama A, Ohisa M, Sakaguchi T, Tahara H, Ohge H, Ohdan H, Kubo T, Kishita E, Kuwabara M, Takahashi K, Tanaka J. Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan. PLoS ONE. 2021;16(2 February).10.1371/journal.pone.0246383

14.  Kato H, Maezawa Y, Ouchi Y, Takayama N, Sone M, Sone K, Takada-Watanabe A, Tsujimura K, Koshizaka M, Nagasawa S, Saitoh H, Ohtaka M, Nakanishi M, Tahara H, Shimamoto A, Iwama A, Eto K, Yokote K. Generation of disease-specific and CRISPR/Cas9-mediated gene-corrected iPS cells from a patient with adult progeria Werner syndrome. Stem Cell Research. 2021;53.10.1016/j.scr.2021.102360

15.  Takayasu T, Shah M, Dono A, Yan Y, Borkar R, Putluri N, Zhu JJ, Hama S, Yamasaki F, Tahara H, Sugiyama K, Kurisu K, Esquenazi Y, Ballester LY. Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors. Scientific Reports. 2020;10(1).10.1038/s41598-020-71161-0

16.  Shiroma Y, Takahashi RU, Yamamoto Y, Tahara H. Targeting DNA binding proteins for cancer therapy. Cancer Science. 2020;111(4):1058-64.10.1111/cas.14355

17.  Shiroma Y, Fujita G, Yamamoto T, Takahashi RU, Kumar A, Zhang KYJ, Ito A, Osada H, Yoshida M, Tahara H. Identification of a selective rela inhibitor based on DSE-FRET screening methods. International Journal of Molecular Sciences. 2020;21(23):1-15.10.3390/ijms21239150

18.  Koi Y, Tsutani Y, Nishiyama Y, Ueda D, Ibuki Y, Sasada S, Akita T, Masumoto N, Kadoya T, Yamamoto Y, Takahashi RU, Tanaka J, Okada M, Tahara H. Predicting the presence of breast cancer using circulating small RNAs, including those in the extracellular vesicles. Cancer Science. 2020;111(6):2104-15.10.1111/cas.14393

19.  Koi Y, Tsutani Y, Nishiyama Y, Kanda M, Shiroma Y, Yamamoto Y, Sasada S, Akita T, Masumoto N, Kadoya T, Takahashi RU, Tanaka J, Okada M, Tahara H. Diagnostic performance of peripheral leukocyte telomere G-tail length for detecting breast cancer. Cancer Science. 2020;111(5):1856-61.10.1111/cas.14378

20.  Ibuki Y, Nishiyama Y, Tsutani Y, Emi M, Hamai Y, Okada M, Tahara H. Circulating microRNA/isomiRs as novel biomarkers of esophageal squamous cell carcinoma. PLoS ONE. 2020;15(4).10.1371/journal.pone.0231116

21.  Yamamoto Y, Tahara H. II. MicroRNAs based targeted therapeutics in breast cancer. Japanese Journal of Cancer and Chemotherapy. 2019;46(12):1841-3)

22.  Witwer KW, Hill AF, Tahara H. Announcing the ISEV2019 special achievement award recipients: Takahiro Ochiya and Marca Wauben. Journal of Extracellular Vesicles. 2019;8(1).10.1080/20013078.2019.1620080

23.  Liu B, Anno K, Kobayashi T, Piao J, Tahara H, Ohdan H. Influence of donor liver telomere and G-tail on clinical outcome after living donor liver transplantation. PLoS ONE. 2019;14(3).10.1371/journal.pone.0213462

24.  Tomomori S, Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Motoda C, Matsumura H, Amioka M, Hironobe N, Okubo Y, Okamura S, Kawazoe H, Nishiyama Y, Tahara H, Chayama K, Kihara Y. Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement. Scientific Reports. 2018;8(1).10.1038/s41598-018-32453-8

25.  Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman MLD, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DRF, Caruso S, Chamley LW, Chang YT, Chaudhuri AD, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FAW, Coyle B, Crescitelli R, Criado MF, D’Souza-Schorey C, Das S, de Candia P, De Santana EF, De Wever O, del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TAP, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DCI, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AGE, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li ITS, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SLN, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-’t Hoen ENM, Noren Hooten N, O’Driscoll L, O’Grady T, O’Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Ostegaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BCH, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IKH, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KMA, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PRM, Silva AM, Skowronek A, Snyder OL, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BWM, van der Grein SG, Van Deun J, van Herwijnen MJC, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MHM, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles. 2018;7(1).10.1080/20013078.2018.1535750

26.  Matsuoka H, Tamura A, Kinehara M, Shima A, Uda A, Tahara H, Michihara A. Levels of tight junction protein CLDND1 are regulated by microRNA-124 in the cerebellum of stroke-prone spontaneously hypertensive rats. Biochemical and Biophysical Research Communications. 2018;498(4):817-23.10.1016/j.bbrc.2018.03.063

27.  Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H. Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells. Scientific Reports. 2018;8(1).10.1038/s41598-018-33139-x

28.  Fujii S, Miura Y, Fujishiro A, Shindo T, Shimazu Y, Hirai H, Tahara H, Takaori-Kondo A, Ichinohe T, Maekawa T. Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations. Stem Cells. 2018;36(3):434-45.10.1002/stem.2759

29.  Clayton A, Buschmann D, Byrd JB, Carter DRF, Cheng L, Compton C, Daaboul G, Devitt A, Falcon-Perez JM, Gardiner C, Gustafson D, Harrison P, Helmbrecht C, Hendrix A, Hill A, Hoffman A, Jones JC, Kalluri R, Kang JY, Kirchner B, Lässer C, Lawson C, Lenassi M, Levin C, Llorente A, Martens-Uzunova ES, Möller A, Musante L, Ochiya T, Pink RC, Tahara H, Wauben MHM, Webber JP, Welsh JA, Witwer KW, Yin H, Nieuwland R. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. Journal of Extracellular Vesicles. 2018;7(1).10.1080/20013078.2018.1473707

30.  Abd El-Hafeez AA, Hosoi T, Nakatsu K, Thon M, Shimamoto A, Tahara H, Ozawa K. TERT enhances the survival rate of human fibroblasts under endoplasmic reticulum, Golgi apparatus, and lysosomal stresses. Biotechnology Letters. 2018;40(6):915-22.10.1007/s10529-018-2544-1

31.  Witwer KW, Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Falcon-Perez JM, Gardiner C, Hochberg F, Kurochkin IV, Lötvall J, Mathivanan S, Nieuwland R, Sahoo S, Tahara H, Torrecilhas AC, Weaver AM, Yin H, Zheng L, Gho YS, Quesenberry P, Théry C. Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility. Journal of Extracellular Vesicles. 2017;6(1).10.1080/20013078.2017.1396823

32.  Tahara H. Telomere G-overhang length measurement method 2: G-tail telomere HPA. Methods in Molecular Biology2017. p. 63-9.

33.  Reiner AT, Witwer KW, Van Balkom BWM, De Beer J, Brodie C, Corteling RL, Gabrielsson S, Gimona M, Ibrahim AG, De Kleijn D, Lai CP, Tvall JL, Del Portillo HA, Reischl IG, Riazifar M, Salomon C, Tahara H, Toh WS, Wauben MHM, Yang VK, Yang Y, Yeo RWY, Yin H, Giebel B, Rohde E, Lim SK. Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles. Stem Cells Translational Medicine. 2017;6(8):1730-9.10.1002/sctm.17-0055

34.  Mateescu B, Kowal EJK, van Balkom BWM, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FWN, Das S, Driedonks TAP, Fernández-Messina L, Haderk F, Hill AF, Jones JC, Van Keuren-Jensen KR, Lai CP, Lässer C, di Liegro I, Lunavat TR, Lorenowicz MJ, Maas SLN, Mäger I, Mittelbrunn M, Momma S, Mukherjee K, Nawaz M, Pegtel DM, Pfaffl MW, Schiffelers RM, Tahara H, Théry C, Tosar JP, Wauben MHM, Witwer KW, Nolte-'t Hoen ENM. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - An ISEV position paper. Journal of Extracellular Vesicles. 2017;6(1).10.1080/20013078.2017.1286095

35.  Kinehara M, Yamamoto Y, Shiroma Y, Ikuo M, Shimamoto A, Tahara H. DNA and Histone Modifications in Cancer Diagnosis. Cancer Drug Discovery and Development2017. p. 533-84.

36.  Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer. Oncotarget. 2016;7(7):8223-39.10.18632/oncotarget.6972

37.  Hosoi T, Nakatsu K, Shimamoto A, Tahara H, Ozawa K. Inhibition of telomerase causes vulnerability to endoplasmic reticulum stress-induced neuronal cell death. Neuroscience Letters. 2016;629:241-4.10.1016/j.neulet.2016.07.027

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